Downstream Process Scientist

About Green Bioactives Ltd.

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Established in 2020, Green Bioactives Ltd (GBL) is an exciting and innovative early-stage company which has developed a sustainable, reliable, economical plant cell-based biomanufacturing platform for plant-derived biomolecules. GBL is pioneering the discovery, development and sustainable production of high value natural products in plant cells and employing production processes that help protect and sustain the environment. GBL aims to become the world’s leading supplier of safe, natural and sustainable plant-derived biomolecules.

 

What we are looking for

A highly experienced, industry-seasoned, well-motivated and talented scientist, you will have an integral role within a fast-growing GBL production team and will be responsible for developing and leading cell culture-related downstream processing (DSP), with a particular focus on knowledge transfer across workstreams and also developing and formulating processes for the purification of an array of plant-derived molecules.

This is a dynamic, exciting and challenging position in a high pace start-up environment where you can blend your science expertise in chemistry or biochemistry with our plant stem cell research and production requirements.

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Key Roles and Responsibilities

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• Leading the design, implementation, optimisation, and training associated with all aspects of downstream processing within the process scaleup and production supply team to ensure that product delivery KPI’s for all company, client and regulatory requirements are met;

• Being the subject matter expert on GBL biomolecule production focussed on downstream process development, scale-up, and tech transfer of products and processes for batch harvesting and purification;

• Developing efficient, scalable and commercially viable scientific methods to enrich, purify and refine, specific plant derived molecules that optimise material recovery, enhance processing efficiency and align with the principles of sustainable green chemistry;

• Adapting and developing appropriate analysis toolsets and techniques to assay the content, purity and activity of plant derived molecules, utilising chromatography (GC, HPLC), mass spectrometry (MS), etc.;

• Working with laboratory-based science colleagues to refine upstream approaches in order to identify and initiate appropriate downstream processes and techniques in relation to individual project and product goals;

• Ensuring all laboratory activity is accurately recorded and maintained – that they meet all organisational protocols and SOPs;

• Develop and implement product specific DSP processes and documentation, batch summary and analytical reports for inclusion within regulatory filings;

• Support line leader to manage resource planning, project management activities, prioritise decisions and resolve complex technical issues to ensure relevant aspects are considered;

• Support recruitment and team development activity including mentoring and development of the production team.

 

What You Will Bring

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Minimum MSc (PhD preferred*) in a Life Sciences discipline, ideally within Plant Biochemistry, Biotechnology, Bioprocessing or Biological Engineering with 7yr+ of industrial post-qualification experience in a Downstream Process Scientist role, leading all downstream scientific process activities within a techno-commercial environment.

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Demonstrable hands-on experience in a number of downstream purification methods for structurally complex biomolecules (e.g. high pressure homogenisation, centrifugation, resin-based purification, chromatography, tangential flow filtration, etc.) 

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Core understanding and/or experience of basic plant cell culture principles and processes.

First class aseptic techniques and exposure to a range of related analytical methods.

Experience of bioprocessing equipment specification, selection and evaluation as well as set-up and operational optimisation is essential.

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In addition, you will have significant experience designing and executing analytical assays such as phenolic content and activity, flavonoid content and activity, terpenoid content and activity using HPLC, GC-MS and possess a clear understanding assay development and validation.

You will have the opportunity to lead key scientific elements of dynamic bio-processing downstream operations. You will be rewarded with an industry leading remuneration package and be afforded a genuine opportunity to play a key role within a dynamic team developing unique, highly innovative products to solve global plant sustainability and yield challenges.

 

Additional information

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• Job title: TBD

• Reports to: Chief Manufacturing Officer.

• Job location: Edinburgh.

• Job type: Full-time.

• Hours of work: Core working hours are between 10:00 am to 4:00 pm. 40 hours per week including a 1-hour lunch break per day.

• Salary: TBD depending upon experience.

• Benefits: 28 days holiday (inclusive of 8 public holidays), pension scheme, EMI share options.

• Right to work in the UK: Preferable but not essential.

• Reference: Upon request.

 

At Green Bioactives we value and encourage diversity and are committed to promoting equality of opportunity and eliminating discrimination. We are committed to offering support and making reasonable adjustments to allow full participation in the recruitment process. Please let us know of any requirements you have and we will consider any reasonable adjustments.

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Eden Scott – Recruitment Partners

Eden Scott is working as recruitment partner with Green Bioactives and any direct or referral applications will be forwarded to them for inclusion in the recruitment campaign – any candidate submissions from alternative sources will not be considered.

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For an informal discussion or for further details on this outstanding opportunity, please call Ian Grant on 07584 676 007 or email ian.grant@edenscott.com.